By Albert J. Bredenoord, André Smout, Jan Tack
This e-book describes the factors and medical administration of useful gastrointestinal issues in a easily comprehensible method, via many transparent illustrations. The concrete and functional recommendation supplied might be such a lot useful within the scientific perform of either the final practitioner and the scientific expert. sensible issues of the gastrointestinal tract, similar to gastroesophageal reflux affliction, practical dyspepsia, and irritable bowel syndrome, are quite common and protracted stipulations. regardless of the new e-book of many medical papers on their prognosis and therapy, a lot is still doubtful, and administration continues to be thought of tough. This practice-oriented publication could be an incredible resource of trustworthy up to date information for all who take care of those patients.
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Extra resources for A Guide to Gastrointestinal Motility Disorders
More rarely esophageal motility is involved in neuropathic diseases, diabetic mellitus, and CIIP (chronic idiopathic intestinal pseudo-obstruction). 7 Gastroesophageal Reﬂux Disease Gastroesophageal reflux is a physiological phenomenon and occurs in healthy subjects approximately twenty times a day. In these subjects reflux is called physiological because it does not cause any damage and it occurs unnoticed without causing any symptoms. Reflux becomes gastroesophageal reflux disease (GERD) when it causes mucosal damage or bothersome symptoms (Fig.
Dopamine-2 receptors are mainly expressed in the stomach and the proximal small bowel. Stimulation of these receptors inhibits smooth muscle contractility, and antagonism of the receptors, through the action of drugs such as domperidone, enhances gastric and small bowel contractions. This can be used, for instance, in the treatment of gastroparesis. An additional advantage of this drug class is the involvement of the same dopamine-2 receptor in the generation of nausea and vomiting, and these symptoms can be controlled by dopamine-2 antagonists.
8 % in the intestine, through luminal actions (Fig. 3). Lubiprostone is a lipophilic prostanoid compound, which acts locally to promote water and chloride secretion through activation of the CCl2 chloride channel on enterocytes. Doing so, it increases stool water content which softens stools and promotes propulsion. Linaclotide is an oligopeptide that acts as an agonist at the guanylate cyclase receptor on enterocytes. Activation of the receptor increases cyclic GMP levels in the enterocyte, which enhances chloride secretion through the cystic fibrosis transmembrane conductance regulator, also increasing stool water content.