Read e-book online Adrenal Actions on Brain PDF

By Bruce S. McEwen (auth.), Dr. Detlev Ganten M.D., Ph.D., Dr. Donald Pfaff Ph.D. (eds.)

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1976; Nurse and O'Lague 1975). Strong cholinergic induction also results in a concomitant lowering of catecholamine synthesis and accumulation (patterson and Chun 1977a) and endogenous catecholamine content (Landis 1980). In a search for factors able to prevent the action of such cholinergiC signals, McLennan et al. (1980) showed that corticosterone inhibits the development of cholinergiC properties in the ganglion in organ culture. Normally after 14 days in culture, choline acetyltransferase activity is high and TH levels have fallen; 10-6 M corticosterone in the medium prevents this change and decreases the choline acetyltransferase/TH activity ratio tenfold.

3 Neural Pathways to the Hypothalamus . . . . . . . . .. 2 Early Delayed Feedback. . . . . . . . . . . . . . . .. 1 Anterior Pituitary. . . . . . . . . . . . . . . .. 2 Hypothalamus. . . . . . . . . . . . . . . . .. 3 Neural Pathways to the Hypothalamus. . . . . . . . .. 3 Late Delayed Feedback . . . . . . . . . . . . . . . .. 6 Mechanisms of Action . . . . . . . . . . . . . . . .

4 Delayed Feedback. . . . . . . . . . . . . . . . . . . 1 Early Delayed Feedback . . . . . . . . . . . . . . . . 2 Late Delayed Feedback . . . . . . . . . . . . . . . .. 5 Sites of Action in Feedback Inhibition . . . . . . . . . . . . 1 Fast Feedback . . . . . . . . . . . . . . . . . . .. 1 Anterior Pituitary . . . . . . . . . . . . . . . .. 2 Hypothalamus.

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