Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia - download pdf or read online

By Andrew Hadley, Peter Soothill

The potent prevention, prognosis, and administration of alloimmune cytopenias has develop into a staff attempt related to hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and study scientists. This publication has been written through specialists of their respective fields to collect the problems of pathogenesis, epidemiology, prevention, analysis, and scientific administration. This accomplished yet obtainable account is broadly cross-referenced to stress the hyperlinks among pathogenesis and scientific sequels, among epidemiology and the reason for screening courses, and among prognosis and healing intervention.

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Extra info for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn

Example text

17 Hilden JO, Gottvall T & Lindblom B (1995). HLA phenotypes and severe Rh(D) immunization. Tissue Antigens, 46, 3131–315. 18 Renkonen KO & Seppäla M (1962). The sex of the sensitizing Rh-positive child. Annals of Medicine, 40, 108–18. 19 Renkonen KO & Timonen S (1967). Factors influencing the immunization of Rh-negative mothers. Journal of Medical Genetics, 4, 166–76. 20 Proulx C, Filion M, Goldman M et al. (1994). Analysis of immunoglobulin class, IgG subclass and titre of HPA-1a antibodies in alloimmunized mothers giving birth to babies with or without neonatal alloimmune thrombocytopenia.

42 Four subclasses of IgG have been identified (IgG1, IgG2, IgG3 and IgG4). The subclasses show significant differences in the hinge region length which comprises of 5, 12, 62 and 12 amino acids in IgG1, IgG2, IgG3 and IgG4, respectively. The structure of the hinge region affects the flexibility of IgG. This flexibility, together with other subclass-related differences in amino acids at key positions within the Fc region, determines the relative ability of the IgG subclasses to interact with Fc␥ receptors.

18 Renkonen KO & Seppäla M (1962). The sex of the sensitizing Rh-positive child. Annals of Medicine, 40, 108–18. 19 Renkonen KO & Timonen S (1967). Factors influencing the immunization of Rh-negative mothers. Journal of Medical Genetics, 4, 166–76. 20 Proulx C, Filion M, Goldman M et al. (1994). Analysis of immunoglobulin class, IgG subclass and titre of HPA-1a antibodies in alloimmunized mothers giving birth to babies with or without neonatal alloimmune thrombocytopenia. British Journal of Haematology, 87, 813–17.

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