By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle
This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in several illness approaches. attainable recommendations to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox legislation of mobile responses* scientific implications of redox signaling and antioxidant treatment
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Additional info for Antioxidant and Redox Regulation of Genes
Cavigelli et al. (1996) and Knebel et al. (1996) have introduced a new aspect into the discussion as to which could be the cellular integrating point that leads to the activation of signaling pathways. Knebel et al. (1996) show that receptor tyrosine kinases (RTKs) are activated (phosphorylated) by inhibition of a phosphatase activity on treatment with UV (A, B, or C), hydrogen peroxide, or iodoacetamide. , dephosphorylation and inactivation of RTKs, was restored on the addition of thiolregenerating agents, if not inhibited irreversibly by iodoacetamide.
1998). Effect of endogenous carotenoids and defective RpoS sigma factor on spontaneous mutation under starvation conditions in Escherichia coli. Evidence for the possible involvement of singlet oxygen. Mutat. Res. 403, 21-28. , Saha-M611er, C. , and Sies, H. (1996). Formation of singlet oxygen in the thermal decomposition of 3-hydroxymethyl-3,4,4-trimethyl-l,2-dioxetane, a chemical source of triplet-excited ketones. Biochem. Mol. Biol. Int. 38, 647-651. , Klotz, L. , and Sies, H. (1997). Toxic and signaling effects of chemically or photochemically generated singlet oxygen in biological systems.
Singlet oxygen is an early intermediate in cytokine-dependent UV induction of interstitial collagenase in human dermal fibroblasts. FEBS Lett. 413, 239-242. 2 Redox Regulation of Gene Expression Dana R. Crawford, * Toshihide Suzuki, * and Kelvin J. A. Davies1 *Department of Biochemistry and Molecular Biology Albany Medical College Albany, New York 12208 tEthel Percy Andrus Gerontology Center University of Southern California Los Angeles, California 90089 Oxidative stress is now known to modulate the expression of a number of genes, both in eukaryotic and in prokaryotic systems.