Download PDF by C. Scarpignato, A. Lanas: Bacterial Flora in Digestive Disease: Focus on Rifaximin

By C. Scarpignato, A. Lanas

Reprint of: Digestion 2006, Vol. seventy three, Suppl. 1 countless numbers of bacterial species make up human intestine vegetation. The gut has no less than four hundred diverse species of micro organism totaling over 1012 organisms. of those, ninety nine% are anaerobic micro organism. The gastrointestinal tract is then uncovered to hundreds and hundreds of bacterial species and overseas antigens and has embedded a distinct and complicated community of immunological and non-immunological mechanisms to guard the host from almost certainly damaging pathogens. fit people are usually tolerant to their very own microbiota, yet such tolerance is impaired in sufferers with either natural and practical gastrointestinal illnesses. The development of the information on microbial-gut interactions in future health and disorder has allowed a extra pathophysiologically-oriented method of a number of demanding medical stipulations. There are presently how you can manage enteric plant life. Antibiotics can selectively reduce tissue invasion and do away with competitive bacterial species or globally reduce luminal and mucosal bacterial concentrations, counting on their spectrum of task. on the other hand, management of priceless bacterial species (probiotics), poorly absorbed nutritional oligosaccharides (prebiotics), or mixed probiotics and prebiotics (synbiotics) can fix a predominance of priceless commensal vegetation. those healing methods should not, after all, jointly specific. Rifaximin, a poorly absorbed antibiotic exact on the gastrointestinal tract, has been lengthy utilized in Italy for the therapy of infectious diarrhea in either adults and youngsters. prior to now few years the appreciation of the pathogenic position of intestine micro organism in different natural and practical gastrointestinal ailments has more and more broadened its scientific use, which now covers hepatic encephalopathy, small gut bacterial overgrowth, inflammatory bowel illness and colonic diverticular sickness. different power medical symptoms are being explored and glance promising. during this factor, best scientists (both Spanish and Italian) speak about - in a sequence of state of the art experiences - the present prestige of the current wisdom on Microbial vegetation in Digestive ailments and investigate the position of rifaximin in different gut-related natural and practical gastrointestinal issues. because it comprises a lot info tricky to assemble from different scattered resources, this quantity can be of curiosity to infectiologists, gastroenterologists and digestive surgeons alike.

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70 Papi C, Koch M, Capurso L: Management of diverticular disease: is there room for rifaximin? Chemotherapy 2005; 51(suppl 1):110– 114. 71 DuPont HL, Jiang ZD: Influence of rifaximin treatment on the susceptibility of intestinal Gram-negative flora and enterococci. Clin Microbiol Infect 2004;10:1009–1011. 72 Venturini AP: Pharmacokinetics of L/105, a new rifamycin, in rats and dogs, after oral administration. Chemotherapy (Basel) 1983; 29: 1–3. 73 Venturini AP: L/105: report on pharmacokinetics in rats, dogs after oral administration and adverse reactions.

Since the correct diagnosis of SIBO by using an indirect approach such as the lactulose-glucose hydrogen breath test is still a matter of debate and important symptoms of FBDs may have explanations other than SIBO, the results of antibiotic treatment of these two different clinical conditions will be analyzed separately. Treatment of FBDs: Is There Room for Antibiotics? Functional Bowel Disorders According to Rome II criteria, the presence of bloating and symptoms related to intestinal gas is frequently encountered in clinical practice, particularly in IBS and functional abdominal bloating [17].

In healthy volunteers neither lactulose nor the control solution induced any modification of sensitivity thresholds. On the contrary, only in the patient group was a reduction of perception and discomfort thresholds evident after lactulose but not after the control solution (table 1). This finding is consistent with the idea that a subgroup of patients may have a heightened visceral sensation (induced or unmasked by colonic fermentation), which allows even low amounts of fermentation products to trigger the symptoms.

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