Read e-book online Basics of blood management PDF

By Petra Seeber

To lessen transfusion-related morbidity and mortality, it's endorsed that an built-in method of blood administration is hired utilizing all on hand instruments to lessen a patient's publicity to donor blood. assembly the necessity for a publication masking the suggestions of blood administration as a pattern in the direction of multidisciplinary blood administration, this new version is a crucial source, supplying healthcare pros with a device to enhance heritage wisdom in blood administration, its association, tools and instruments. practising clinicians should be absolutely ready to effectively begin and run blood administration courses.

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Cytokines involved in the inflammatory process act on different stages of erythropoiesis. Interferon-γ downregulates the EPO receptor at the surface of erythroid precursors [4]. Tumor necrosis factor suppresses EPO production in the kidneys. Optimizing the treatment of infection and inflammation reduces certain cytokine levels and may recover EPO responsiveness. In some cases, however, it may be necessary to treat inflammation-related anemia with high doses of rHuEPO, since higher doses may overcome the inhibitory effects of cytokines in these cases [38].

60. Glaspy J. Phase III clinical trials with darbepoetin: implications for clinicians. Best Pract Res Clin Haematol 2005;18: 407–416. 61. Macdougall IC. Novel erythropoiesis stimulating agents: A new era in anemia management. Clin J Am Soc Nephrol 2008;3:200–207. 62. Brunkhorst R, Bommer J, Braun J, et al. Darbepoetin alfa effectively maintains haemoglobin concentrations at extended dose intervals relative to intravenous or subcutaneous recombinant human erythropoietin in dialysis patients. Nephrol Dial Transplant 2004;19:1224–1230.

14. Schreiber S, Howaldt S, Schnoor M, et al. Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease. N Engl J Med 1996;334:619–623. Anemia Therapy I: Erythropoiesis-Stimulating Agents 15. Corwin HL, Gettinger A, Rodriguez RM, et al. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Crit Care Med 1999;27:2346–2350. 16. Gabriel A. High-dose recombinant human erythropoietin stimulates reticulocyte production in patients with multiple organ dysfunction syndrome.

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