Basophil and Mast Cell Degranulation and Recovery by Ann M. Dvorak PDF

By Ann M. Dvorak

Basophils and mast cells are related yet designated secretory cells with a well-documented position in immediate-hypersensitivity reactions. The presence of those cells in a number of cellphone­ mediated allergic reaction reactions, in tissues of a number of ailments, and as an element of the host response to damage and service in several conditions is widely known. unlock of kept and newly generated mediators of irritation from basophils and mast cells contributes to the cascade of pathogenetic occasions in conditions lower than which those liberate reactions happen. regardless of insights bought via reports of those pathologic occasions, the function of basophils and mast cells and their secretory items in well-being isn't identified. during this e-book, I evaluate a lot of the structural information about basophils and mast cells of a number of species. Ultrastructural experiences of rat mast cells traditionally precede and quantitatively exceed related experiences of basophils and mast cells of alternative species. as a result, I first assessment those heritage stories as an entity. Then I speak about the contents of 2 widespread organelles-granules and lipid bodies-in basophils and mast cells of a number of species. The ultrastructural morphology of basophils and mast cells in 3 species is gifted intimately to set up acceptable directions for his or her attractiveness and to supply normal ideas for research that are applicable for the id of those cells in different species as well.

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Multiple ultrastructural studies have revealed similar crystals within human basophil granules in mature cells (Figure 20) (A . M. Dvorak, 1988a; A. M. Dvorak and Ackerman, 1989; A. M . Dvorak and Monahan , 1982;A. M. , 40 Chapter 3 FIGURE 16. Guinea pig basophils showing a prominent ANAE-positive ectoenzyme. Cytoplasmic granules are ANAE negative. (A) Unfixed basophils display extensive amounts of ANAE. (B) Less positive ectoenzyme after brief fixation in a mixture of aldehydes. LID. Contents of Granules and Lipid Bodies 41 FIGURE 17.

M (B). 56 Chapter 3 FIGURE 34. Human lung mast cell preparation similar to that in Figure 33A, showing a large cluster of cytoplasmic lipid bodies and two scroll granules (arrowheads). Note that there are several focal lucent areas in lipid bodies with residual linear material remaining (arrows). Lm. FIGURE 35. Human lung mast cell cultured for 6 hr, showing vesicular structures within the large lipid body. Numerous scroll granules are also present. Lm. Contents of Granules and Lipid Bodies 57 N FIGURE 36.

Peroxidase activity has been found in human and guinea pig basophil granules (Ackerman and Clark, 1971; A. M. M. , 1972a, 1980b, 1985c,d; Dvorak and Dvorak, 1975; Nichols and Bainton, 1973). Although initially this FIGURE 13. Guinea pig basophil extruding membrane-free granules from an open degranulation sac in the cytoplasm, 12 hr after exposure to a degranulation stimulus. Silver grains represent [3 H]DFP associated with granules and with plasma and degranulation sac membranes (arrows). 6 fLrn .

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