By Akhlaq A. Farooqui
It is changing into more and more glaring that the deficiency of n-3 fatty acids in nutrition isn't just linked to cardiovascular ailments, but additionally fascinated with stroke, epilepsy and different neurological and neurodegenerative illnesses, reminiscent of Alzheimer disorder, Parkinson affliction, and peroxisomal illnesses. In his most recent e-book, Beneficial results of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands at the prestige and healing value of n-3 fatty acids (major parts of fish oil) and their mediators in basic mind and people with neurodegenerative and neuropsychiatric ailments. Farooqui provides some great benefits of n-3 fatty acids on Western nutrition, that's enriched in n-6 fatty acids (major parts of vegetable oil) and will advertise the above neurological issues. The ebook will current readers with leading edge and finished info on metabolism and roles of neural membrane n-3 fatty acids.
Neuroscientists, clinicians, neurologists, neuropathologists, opthamologists, dietitians, and nutritionists will locate this booklet helpful for figuring out the molecular foundation of n-3 fatty acids and their lipid mediators (resolvins and neuroprotectins) in neuroprotection in acute neural trauma (stroke, spinal wire trauma and head damage) and neurodegenerative diseases.
About the Author:
Dr. Akhlaq A. Farooqui is a pacesetter within the box of mind phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, and glutamate-induced neurotoxicity. He has found the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) and diacyl- and monoacylglycerol lipases in brains from sufferers with Alzheimer ailment. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and raises degrees of eicosanoids which may be concerning the lack of synapses in brains of sufferers with Alzheimer illness. Dr. Farooqui has released leading edge examine at the iteration and identity of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity via lipidomics. He has formerly authored 4 monographs: Glycerophospholipids in mind: Phospholipase A2 in Neurological Disorders (2007); Neurochemical features of Excitotoxicity (2008); Metabolism and services of Bioactive Ether Lipids in Brain (2008); and Hot subject matters in Neural Membrane Lipidology (2009). All monographs are released via Springer.
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Extra info for Beneficial Effects of Fish Oil on Human Brain
It is hypothesized that the effects of trans fatty acids on insulin sensitivity may be mediated through alterations in gene expression. In vitro studies demonstrate that the extent of trans-18 : 2 fatty acids incorporation is twofold greater in the glycerophospholipid fraction of human aortic endothelial cells than that of cis-18 : 2. , 2008). 5- to 2-fold, respectively. Neutrophil and monocyte adhesion to human aortic endothelial cells monolayers is also proportional to adhesion molecule expression.
1988). However, effects on very low-density lipoprotein (VLDL) synthesis and/or VLDL triacylglycerol removal rate via increased lipoprotein lipolysis have not been ruled out (Kasim-Karakas, 1995). Fish oil ingredients may limit the supply of lipid substrates for triacylglycerol synthesis. , 1991). Thus, in rat liver, synthesis and secretion of triacylglycerol and cholesterol ester are reduced by 50–80% in the presence of EPA in comparison with oleic acid. Reduced synthesis of triacylglycerol and cholesterol ester is seen when EPA and oleic acid are given together.
JNK activity is increased by low-dose DHA, but not by EPA. DHA and EPA have no significant effect on p38 activity. Low dose of DHA inhibits cyclin E activity. DHA upregulates the expression of the cell cycle inhibitor p21, but not p27. EPA has no effect on p21 or p27. It is proposed that the differential effect of low-dose DHA vs EPA in suppressing mesangial cells mitogenesis may be related to downregulation of ERK and cyclin E activity and to induction of p21. , 2003). 8 Effects of Fish Oil on Plasma Lipids A predominance of small, dense, low-density lipoprotein (LDL) and increased plasma triacylglycerol levels are increased risk for the development of coronary heart disease (Griffin, 2001).