Download e-book for iPad: Biomembrane frontiers: nanostructures, models, and the by Amalie L. Frischknecht, Laura J. D. Frink (auth.), Roland

By Amalie L. Frischknecht, Laura J. D. Frink (auth.), Roland Faller, Marjorie L. Longo, Subhash H. Risbud, Thomas Jue (eds.)


Series Editor Thomas Jue, PhD

Handbook of contemporary Biophysics brings present biophysics issues into concentration, in order that biology, scientific, engineering, arithmetic, and physical-science scholars or researchers can study primary innovations and the appliance of latest thoughts in addressing biomedical demanding situations. Chapters explicate the conceptual framework of the physics formalism and illustrate the biomedical functions. With the addition of challenge units, publications to additional examine, and references, the reader can proceed to discover independently the information presented.

Volume II: Biomembrane Frontiers: Nanostructures, versions, and the layout of Life

Editors: Roland Faller, PhD, Thomas Jue, PhD, Marjorie L. Longo, PhD, and Subhash H. Risbud, PhD

In Biomembrane Frontiers: Nanostructures, versions, and the layout of Life, admired researchers have validated a starting place for the research of biophysics on the topic of the subsequent topics:

  • Perspectives: Complexes in drinks, 1900–2008
  • Molecular conception utilized to Lipid Bilayers and Lipid–Protein Interactions
  • Membrane Elasticity and Mediated Interactions in Continuum conception: A Differential Geometric Approach
  • Structure and Dynamics of Lipid Monolayers: concept and Applications
  • Multiscale Modeling of Supported Lipid Bilayers
  • Collective Dynamics in Lipid Membranes:
  • From Pore Formation to Flip-Flops
  • Spatiotemporal association of Spin-Coated Supported version Membranes
  • Nanopore research of Nucleic Acids: Single-Molecule
    Studies of Molecular Dynamics, constitution, and Base Sequence
  • Complex purposes of straightforward FRAP on Membranes
  • Punching Holes in Membranes: How Oligomeric
    Pore-Forming Proteins and Lipids Cooperate to shape Aqueous Channels in Membranes
  • Morphogens, Membranes and Mechanotransduction in Articular Cartilage
  • Lifecycle of a Lipoprotein from a Biophysical Perspective
  • Targeting Apolipoproteins in Magnetic Resonance Imaging

About the Editors

The editors are the world over well-known biomembrane specialists and feature released generally at the constitution, dynamics, and serve as of version and mobile membranes. Roland Faller is an affiliate Professor and the Joe & Essie Smith Endowed Chair within the division of Chemical Engineering & fabrics technological know-how on the collage of California Davis. He develops and makes use of glossy molecular simulation thoughts for gentle condensed topic structures, quite biomembranes. Thomas Jue is a Professor within the division of Biochemistry and Molecular drugs on the collage of California Davis. He develops and applies magnetic resonance innovations to check biochemical legislation in vivo. Marjorie L. Longo is a professor within the division of Chemical Engineering and fabrics technological know-how on the college of California Davis. She applies microscopy innovations to check floor and delivery homes of lipid bilayers and monolayers. Subhash H. Risbud is the Blacutt-Underwood distinctive Professor of fabrics technological know-how within the division of Chemical Engineering and fabrics technology on the college of California at Davis and a traveling Professor at Stanford collage. His crew develops new fabrics for nano- and biotechnology. The fabrics comprise glasses, ceramics, and nanoporous substrates for organic membranes.

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Extra resources for Biomembrane frontiers: nanostructures, models, and the design of life

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Reprinted with permission from [16]. Copyright © 2006, The Biophysical Society. tion and the maximum concentration at which we also obtain stable bilayer solutions to the DFT. Thus we see changes in the area per lipid, relative to the area per lipid with no alcohol AL 0 , of 'AL /AL 0 between 16 and 24% at the upper limits of bilayer stability [15], which is similar to Ly and Longo's results of about a 16% change for ethanol and a 27% change for butanol [86]. The shape of the 'AL /AL 0 vs. concentration curves is also qualitatively similar to Figure 12 in [86].

41) where UD ( x ) is the density profile of any single site type D on the lipid and * L is the total number of lipid molecules in the system. In a self-assembling system such as our lipid/solvent model, it is possible to have multiple solutions to the DFT equations. To explore these solutions, we used a pseudo-arclength continuation algorithm of Keller [75] as implemented in the LOCA library of Salinger et al. [76]. Given one solution to the equations, this algorithm will follow a curve of solutions as a function of some parameter in the model, for example, as a function of temperature T.

18), ': s is the difference in free energy between the pure solvent and the bulk homogeneous reservoir, and A is the total area. Interestingly, the excess free energy, :ex , is also exactly the net surface tension across the bilayer: J  :ex . 40) In biological membranes, the net surface tension across the bilayer is zero. If the surface tension were positive, the bilayer would shrink, whereas if negative the bilayer would expand. The stable point is thus when J  : ex  0 . The basic structural quantities of interest for a fluid bilayer are the bilayer thickness t and the density of lipids in the bilayers, usually reported as the area per lipid AL .

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