By Elizabeth A. Montgomery MD, Lysandra Voltaggio MD
Gastrointestinal mucosal biopsies are an lively a part of the pathologist’s day and feature elevated some time past few years as endoscopic screening has turn into extra average. This new full-color moment version of Biopsy Interpretation of the Gastrointestinal Tract Mucosa has been multiplied into concise, complete volumes to provide extra whole insurance of either non-neoplastic and neoplastic entities. just like the different books within the Biopsy Interpretation Series, those volumes are sensible references for pathologists to exploit while making diagnostic judgements in keeping with biopsy specimens.
Volume 2 of this moment variation makes a speciality of interpretation of neoplastic gastrointestinal mucosal biopsies. assurance is geared to day-by-day perform and contains mucosal biopsies from the esophagus, abdominal, small gut, huge gut, and anus. A better half web site will contain all the three hundred print illustrations plus an extra 750 e-figures.
Volume 1 specializes in non-neoplastic biopsies and released in November 2011.
Read or Download Biopsy Interpretation of the Gastrointestinal Tract Mucosa: Volume 2: Neoplastic PDF
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Extra resources for Biopsy Interpretation of the Gastrointestinal Tract Mucosa: Volume 2: Neoplastic
In “normal polarity,” the long axis of the nucleus remains perpendicular to the basement membrane, and the nuclei are aligned parallel to one another. “Loss of nuclear polarity” refers to the loss of this perpendicular orientation and a random, “jumbled” appearance of the nuclei, in relation to the basement membrane and one another (Fig. 13). “Inflammation and erosions/ulcers” are a potential component that add difficulty and are assessed at both scanning and high magnification. They can obscure a truly malignant lesion or impart worrisome cytologic alterations that are attributable to a reparative process.
42. advantage. Rare examples are associated with an intact overlying squamous epithelium with the neoplastic cells dipping down from an abnormal basal layer (“basal layer type”) (Fig. 51, e-Figs. 198). 44 Basaloid squamous carcinoma. Squamous carcinomas with basaloid pattern are not common in the esophagus and are characterized by nests of dark, tightly packed cells with scant cytoplasm. 45 Sarcomatoid squamous carcinoma. These lesions resemble high-grade pleomorphic sarcomas but are poorly differentiated carcinomas.
There were multiple lesions in five cases. Many cases showed endoscopic evidence of hiatal hernia, gastroesophageal reflux, or esophagitis. No examples of Barrett esophagus were found. In our own material from a busy gastroenterology practice, about 70 cases have been biopsied at our hospital in the past 20 years. Squamous papillomas are seen as tiny polyps at endoscopy. Mucosal biopsies appear as small whitish nodules. On histologic evaluation, these lesions are simply composed of bland polypoid squamous mucosa with fibrovascular cores (Figs.