Wai Yiu Cheung's Calcium and Cell Function PDF

By Wai Yiu Cheung

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Copyright (1983) American Chemical Society. 2 philic address (-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys) (Gysin and Schwyzer, 1983). Experiments with A C T H j _ indicated that the N-terminal decapeptide unit enters lipid bilayers, where it assumes an α-helical conformation, while the hydrophilic C-terminal tetradecapeptide remains on the polar interface as an irregular structure, with peptide bonds oriented perpendicularly to the bilayer (Gremlich et al, 1983, 1984; Gysin and Schwyzer, 1984). Similar phenomena may be involved in the binding of specific peptides by calmodulin.

1977) and 1-106 but not with 1-90 and 107-148 (Walsh et al, 1977). None of the known calmodulin fragments appears to affect the activity of calcineurin. , 1981). —to activate Phosphorylase kinase by stimulating autophosphorylation (Malencik and Fischer, 1982). We also find that fragment 7 2 - 1 4 8 is a weak inhibitor of smooth muscle myosin light chain kinase. , 1984). , 1983). , 1984). This result may apply to peptides as well since Giedroc et al. (1983a) covalently cross-linked up to 2 mol ß-endorphin/mol calmodulin.

Hoar, P. , Cassidy, P. , and Malencik, D. A. (1981). Calciumregulatory mechanisms. Functional classification using skinned fibers. J. Gen. Physiol. 77, 177-190. Kincaid, R. , Vaughan, M . , Osborne, J. C , and Tkachuk, V. A. (1982). Ca -dependent interaction of 5-dimethylamino-naphthalene-l-sulfonyl-calmodulin with cyclic nucleotide phosphodiesterase, calcineurin, and troponin I. J. Biol. Chem. 257, 10638-10643. Klapper, M. Η. (1977). The independent distribution of amino acid near neighbor pairs into polypeptides.

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