Download e-book for kindle: Chemical modification of biological polymers by Roger L. Lundblad

By Roger L. Lundblad

Examining the chemical amendment of organic polymers and the rising functions of this expertise, Chemical amendment of organic Polymers displays the swap in emphasis during this subsection of biotechnology from the learn of protein constitution and serve as towards functions in therapeutics and diagnostics.


  • The simple natural chemistry of the amendment proteins, nucleic acids, oligosaccharides, polysaccharides, and their applications
  • New analytical applied sciences used to signify the chemical amendment of organic polymers
  • Identification of in vivo, non-enzymatic chemical amendment of organic polymers
  • Specific chemical changes to generate biopharmaceutical items

This e-book covers the fundamentals at the natural chemistry underlying the chemical amendment of biopolymers, together with updates at the use of varied chemical reagents. It describes the present prestige of chemical amendment of organic polymers and rising purposes of this expertise in biotechnology. those applied sciences are vital for the manufacture of conjugate proteins utilized in drug supply, for the coaching of nucleic acid microarrays, and for the coaching of hydrogels and different fabrics utilized in tissue engineering.

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Biol. 388, 195–206, 2009. 119. , Volpini, R. , Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation, J. Am. Chem. Soc. 131, 12908–12909, 2009. Functional Groups in Biopolymers and Factors Influencing Reactivity 19 120. , Simple method for determining nucleobase pKa values by indirect labeling of a pKa of neutrality in dsDNA, J. Am. Chem. Soc. 126, 10200–10201, 2004. 121. , Calculation of pKas in RNA: On the structural origins and functional roles of protonated nucleotides, J.

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Biol. Chem. 263, 3729, 1988. 197. , Jr. , A method for characterizing the type and numbers of groups involved in enzyme action, J. Biol. Chem. 236, 1973, 1961. 198. , Relation between modification of functional groups of proteins and their biological activity. I. A graphical method for the determination of the number and type of essential groups, Sci. Sin. 11, 1535, 1962. 199. , Kinetics of substrate reaction during irreversible modification of enzyme activity, Adv. Enzymol. 61, 381, 1988. 200.

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