Hak Choy's Chemoradiation in cancer therapy PDF

By Hak Choy

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2. RNA-Directed Effects of Fluropyrimidines Although FdUrd produces only DNA-medicated cyotoxicity, 5-FU can also be metabolized to fluorouracil monophosphate (FUMP) and ultimately to fluorouracil triphosphate (FUTP), which can be incorporated into RNA in place of uridine triphosphate (UTP). In other words, incorporation of 5-FU into RNA mimics uracil de novo synthesis and affects the production of ribosomal RNAs (rRNAs) (16,17). 5-FU also affects several aspects of messenger RNA (mRNA) function, including transcription (18), translation (19), and slicing (20).

Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression. Cancer Res 1992; 52(10):2951–2956. 83. Kopp R, Noelke B, Sauter G, et al. Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas. Cancer Res 1991; 51(1):205–210. 84. Fabbro D, Ruetz S, Bodis S, et al. PKC412—a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des 2000; 15(1):17–28. 85. Zaugg K, Rocha S, Resch H, et al. Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412.

O’Brian C, Vogel VG, Singletary SE, et al. Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 1989; 49(12):3215–3217. 82. Benzil DL, Finkelstein SD, Epstein MH, et al. Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression. Cancer Res 1992; 52(10):2951–2956. 83. Kopp R, Noelke B, Sauter G, et al. Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.

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