By Monika Göőz
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Extra resources for Chronic Kidney Disease
The Treat-to-Goal study compared sevelamer-HCl to calcium-containing phosphate binders, analyzing the progression of coronary artery and aortic calcification (by EBCT) in prevalent HD patients over 1 year. Although calcification scores progressed with calcium- 38 Chronic Kidney Disease (a) (b) Fig. 3. Extent and localization of different types of atherosclerotic lesion calcification in apoE−/− mice with CRF. von Kossa staining. a) solid type of plaque calcification, magnification ×25; b) non-plaque calcification, magnification×25.
2008). 1 Classification of renal osteodystrophy by bone biopsy Bone biopsy is performed to understand the pathophysiology and course of bone disease, to relate histological findings to clinical symptoms of pain and fracture, and to determine The New Kidney and Bone Disease: Chronic Kidney Disease – Mineral and Bone Disorder (CKD–MBD) 31 whether treatments are effective. The traditional types of renal osteodystrophy have been defined on the basis of turnover and mineralization as follows: mild, slight increase in turnover and normal mineralization; osteitis fibrosa, increased turnover and normal mineralization; osteomalacia, decreased turnover and abnormal mineralization; adynamic, decreased turnover and acellularity; mixed, increased turnover with abnormal mineralization.
In the general population, the overall coronary calcium score can be considered as a measure of the overall burden of coronary atherosclerosis. The American College of Cardiology/American Heart Association document indicates that the relationship between CAC and cardiovascular events in the CKD population is less clear than that in the non-CKD population because of a relative lack of informative studies and the possibility that medial calcification may not be indicative of atherosclerotic disease severity.