Download e-book for iPad: Clinical Malignant Hematology by Mikkael Sekeres, Matt Kalacyio, Brian Bolwell

By Mikkael Sekeres, Matt Kalacyio, Brian Bolwell

The basically entire advisor to the medical administration of hematologic and lymphatic cancers

4 megastar DOODY'S overview! "This might be an awesome and a must have publication for somebody excited by the day-by-day care of sufferers with hematologic malignancies. it might be fairly invaluable for physicians-in-training attempting to make feel of the ever extra advanced healing procedures for those patients....This is a distinct e-book that gives simply available info that may be helpful to nearly any training oncologist or hematologist."-- Doody's evaluation provider

Filling an unmet want within the scientific literature, this commanding, just-in-time reference sheds gentle at the complete spectrum of cancers within the blood, bone marrow, and lymphatic process (leukemia, lymphoma, myeloma). scientific Malignant Hematology is edited through employees participants from the well known Taussig melanoma heart on the Cleveland medical institution, which has pioneered one of the most very important scientific discoveries and therapy traits in fresh years.

Look within and you may see a constant, unified sufferer administration technique in every one bankruptcy, in addition to a streamlined three-section structure that expertly examines ontogeny and body structure of blood cells, myeloid neoplasia, and lymphoid neoplasia. you are going to additionally locate never-before-published views and special options for dosing and different serious components that replicate the most recent scholarship of this more and more very important field.

Features

  • Full assurance of all therapy modalities --chemotherapy, monoclonal antibodies, and hematopoietic stem telephone transplantation
  • an in depth, regimen-based orientation in each one bankruptcy
  • Abundance of medical images and photomicrographs showing examples of peripheral blood smears and bone marrow aspirates
  • Uniform headings and tables in every one bankruptcy, which exhibit particular tips on the work-up, staging, analysis, differential analysis, and therapy of hematologic malignancies
  • Nearly 2 hundred illustrations

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    Extra resources for Clinical Malignant Hematology

    Example text

    Am J Epidemiol 160(1):19–25, 2004. Altekruse SF, Henley SJ, Thun MJ: Deaths from hematopoietic and other cancers in relation to permanent hair dye use in a large prospective study (United States). Cancer Causes Control 10(6):617–625, 1999. : A prospective study of permanent hair dye use and hematopoietic cancer. J Natl Cancer Inst 86(19):1466–1470, 1994. Tajima K, Cartier L: Epidemiological features of HTLV-I and adult T cell leukemia. Intervirology 38(3–4):238–246, 1995. Rowley JD, Golomb HM, Vardiman J: Acute leukemia after treatment of lymphoma.

    Rearranged in AML patients without structural chromosome abnormalities involving band 11q23. 45 MOLECULAR GENETICS MUTATIONS IN AML-ASSOCIATED TRANSCRIPTION FACTORS CEBPA The CEBPA gene encodes a transcription factor expressed mainly in myelomonocytic cells that is Chapter 2 ■ Molecular Biology, Pathology, and Cytogenetics of Acute Myeloid Leukemia essential for granulopoiesis, showing cell-type-specific and differentiation-stage-specific expression patterns. 47,48 These include N-terminal nonsense mutations resulting in a premature termination of the full-length protein with dominant-negative properties, and C-terminal in-frame mutations resulting in a decrease of DNA-binding potential.

    Tajima K, Cartier L: Epidemiological features of HTLV-I and adult T cell leukemia. Intervirology 38(3–4):238–246, 1995. Rowley JD, Golomb HM, Vardiman J: Acute leukemia after treatment of lymphoma. N Engl J Med 297(18):1013, 1977. : Leukemia following Hodgkin’s disease. N Engl J Med 322(1):7–13, 1990. Kantarjian HM, Keating MJ: Therapy-related leukemia and myelodysplastic syndrome. Semin Oncol 14(4):435–443, 1987. Rowley JD, Olney HJ: International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: overview report.

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