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By H. E. Blum, W. Gerok (auth.), S. Matern (eds.)

The final decade has visible large advancements in lots of fields of gastroenterology and hepatology. the purpose of this sequence is to focus on a few of these themes that deserve specific curiosity. examine within the box of viral hepatitis has been very severe and winning lately. The hepatitis B virus is without doubt one of the top explored on the present point of virology. not just the nucleotid series of the viral DNA could be decoded, but additionally the amino acid compounds of its genetic items are recognized this day. because the strategies of molecular biology have more and more discovered entry to medical laboratory use, hepatitis B virus an infection can function an instance for the significance of molecular biology in medical hepa­ tology. one other instance for the interdependence of uncomplicated technological know-how and clini­ cal medication represents the study on bile acid metabolism. The research of bile acids has published new diagnostic ways to hepatic and intestinal problems. advertisement kits for the regimen size of serum bile acids in scientific laboratories by means of enzymatic or radioimmunologic strategies at the moment are on hand. The diagnostic worth of those measurements in gastroenterology and hepatology might be outlined. one other point of bile acid learn ends up in new in keeping with­ spectives within the remedy of gallstone sickness. The dissolution of ldl cholesterol gallstones via chenodeoxycholic acid (therapy) should be quoted because the top instance for the advance of latest phar­ macotherapeutic ideas derived from uncomplicated bile acid research.

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Matheson, D. and Poon, M. C. (1985). Hepatitis B virus DNA is enriched in polymorphonuclear leukocytes. , Watanabe, M. and Nagashima, H. (1985). Hepatitis B virus DNA replication in peripheral blood mononuculear cells. , Tiollais, P. and Brechot, C. (1984). Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus. J. Gen. , 65, 651-5 Korba, B. , Tennant, B. , Yoakum, G. , Purcell, R. H. and Gerin, J. L. (1986). Hepadna virus infection of peripheral blood lymphocytes in vivo: Woodchuck and chimpanzee models of viral hepatitis.

23. into naturally occurring bile acids in vitro. In Schiff, L. et al. (eds), Bile Salt Metabolism, pp. 115-26. (Springfield, II: Thomas) Krisans, S. , Thompson, S. , Pena, L. , Kok, E. and Javitt, N. B. (1985). Bile acid synthesis in rat liver peroxisomes: metabolism of 26hydroxycholesterol to 3p-hydroxy-5-cholenoic acid. J. , 26, 1324-32 Myant, N. B. and Mitropoulos, K. A. (1977). CholesteroI71X-hydroxylase. J. , 18, 135-53 Mosbach, E. H. (1972). Hepatic synthesis of bile acids. Biochemical steps and mechanisms of rate control.

22. 23. into naturally occurring bile acids in vitro. In Schiff, L. et al. (eds), Bile Salt Metabolism, pp. 115-26. (Springfield, II: Thomas) Krisans, S. , Thompson, S. , Pena, L. , Kok, E. and Javitt, N. B. (1985). Bile acid synthesis in rat liver peroxisomes: metabolism of 26hydroxycholesterol to 3p-hydroxy-5-cholenoic acid. J. , 26, 1324-32 Myant, N. B. and Mitropoulos, K. A. (1977). CholesteroI71X-hydroxylase. J. , 18, 135-53 Mosbach, E. H. (1972). Hepatic synthesis of bile acids. Biochemical steps and mechanisms of rate control.

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