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Additional info for Colorectal Cancer (2006)
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Loss of imprinting of the insulin-like growth factor II gene (IGF2) has been found in the normal colonic mucosa in around one-third of patients with colorectal cancer, a threefold excess in comparison to controls (164). 7) in circulating lymphocytes, indicating it may be a marker for colorectal cancer. However, further evidence also indicates that not only is loss of IGF2 imprinting heritable but it also is associated with increased tumor burden in an animal model (165). Thus it is possible that epigenetic mechanisms are also involved in colorectal cancer susceptibility, further complicating attempts to identify the genes contributing to the disease burden.