Colorectal cancer in clinical practice : prevention, early by Rozen, P PDF

By Rozen, P

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Extra resources for Colorectal cancer in clinical practice : prevention, early detection, and management

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2). Eventually, further biological changes may occur that confer metastatic capacities. e. 4). The likelihood of accumulating such events increases with time such that cancer incidence rises as an exponential function of age. 9 While sometimes called the polyp–cancer sequence, this is technically incorrect in that ‘polyp’ simply describes a shape and need not refer to an early neoplasm. 10 Dysplasia is characterized by progressive cytologic and architectural abnormalities, but the cells are not invasive.

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Aberle H, Schwartz H, Kemler R, Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 1996; 61: 514–23. 7. Kinzler K, Vogelstein B, Gatekeepers and caretakers. Nature 1997; 386: 761–3. 8. *Fearon ER, Vogelstein B, A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759–67. 9. *Morson BC, Evolution of cancer of colon and rectum. Cancer 1974; 34: 845–9. 10. Muto T, Bussey HJR, Morson BC, The evolution of cancer of the colon and rectum.

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