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Extra resources for Colorectal cancer in clinical practice : prevention, early detection, and management
2). Eventually, further biological changes may occur that confer metastatic capacities. e. 4). The likelihood of accumulating such events increases with time such that cancer incidence rises as an exponential function of age. 9 While sometimes called the polyp–cancer sequence, this is technically incorrect in that ‘polyp’ simply describes a shape and need not refer to an early neoplasm. 10 Dysplasia is characterized by progressive cytologic and architectural abnormalities, but the cells are not invasive.
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