Commercial Plant-Produced Recombinant Protein Products: Case - download pdf or read online

By John A. Howard, Elizabeth E. Hood

Attention has lately grew to become to utilizing vegetation as hosts for the construction of commercially very important proteins. The twelve case reports during this quantity current winning suggestions for utilizing vegetation to provide business and pharmaceutical proteins and vaccine antigens. They learn intimately initiatives that experience advertisement strength or items that experience already been commercialized, illustrating the benefits that vegetation provide over bacterial, fungal or animal cell-culture hosts. there are lots of symptoms that plant protein creation marks the start of a brand new paradigm for the economic creation of proteins that, over the subsequent decade, will extend dramatically.

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Importantly, it was stable under normal maize processing conditions (storage at 10  C, followed by dry milling, fractionation, and hexane extraction). This made it competitive with egg-derived avidin (Hood et al. 1997). The commercial success of avidin was followed by β-glucuronidase, which was produced with a yield of approximately 80 mg per kg of dry seeds. This product was also similar in structure to its native counterpart and stable under typical maize processing conditions (Witcher et al.

This example also highlights the advantages of a broad range of alternative hosts in molecular farming—the same protein can be produced in tobacco without the need for additional processing steps because the troublesome protease is not present in this species (Pogue et al. 2010). Commercial molecular farming based on seeds has also been established by other companies, which have developed economically viable DSP strategies. For example, Ventria Bioscience (Fort Collins, CO) produces several vaccines and proteins such as human albumin, transferrin, lactoferrin, and lysozyme in rice seeds.

Fischer et al. Pogue GP, Vojdani F, Palmer KE et al (2010) Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems. Plant Biotechnol J 8:638–654 Rademacher T, Sack M, Arcalis E et al (2008) Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans. Plant Biotechnol J 6:189–201 Ramessar K, Rademacher T, Sack M et al (2008) Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

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