New PDF release: Diseases and Disorders - Hemophilia

By Beverly Britton

After centuries of incorrect information approximately hemophilia, the technology of genetics and the data of the way blood clots opened the door for realizing, new remedies, and a extra basic way of life for victims of the affliction. Researchers proceed pursuing a therapy for hemophilia within the twenty first century. (20051001)

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Christmas Disease The knowledge of hemophilia advanced in the mid-1900s with the discovery of another form of hemophilia called Christmas disease. Christmas disease is an alternate name for hemophilia B, named for a ten-year-old British boy, Stephen Christmas, who was the first recognized with this type of hemophilia. A. S. Douglas of Oxford University and Dr. Mcfarlane, a hematologist, published a paper describing Stephen Christmas’s disease as different from hemophilia A, which before that time was thought to be the Hemophilia Throughout History 31 only type of hemophilia.

Individual blood donations lacked enough clotting factor, so the products were made from pools of donors—sometimes 15,000 to 60,000 people. Therefore, the chances of the product containing HIV were enormous. Until 1985, mandatory screening of blood donors for HIV was not required. As a result, in the 1980s, half of all hemophiliacs became infected with HIV through contaminated factor products, and 90 percent of those with severe hemophilia were infected because of their greater use of blood products.

This discovery was important because for the first time, sufficient amounts of the missing clotting factor could be administered without adding a large volume of fluid to the person’s circulatory system and putting unnecessary strain on the heart. The new substance was named cryoprecipitate. Unlike giving whole blood transfusions, cryoprecipitate did not need to match a person’s specific blood type. Administration required mixing the thawed plasma with a saline solution and giving it to the patient through a needle into a vein.

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