Download PDF by Yashwant Pathak, Deepak Thassu: Drug Delivery Nanoparticles Formulation and Characterization

By Yashwant Pathak, Deepak Thassu

Nanoparticles, items of nanotechnology, are of accelerating curiosity to the pharmaceutical neighborhood. they could elevate drug solubility, improve bioavailability, let tissue concentrating on, supply lowered side-effects, and enhance healing efficacy. proposing the main pertinent and useful matters within the production and organic software of nanoparticles, this resource provides state of the art clinical contributions by way of professional gurus within the box.

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Extra info for Drug Delivery Nanoparticles Formulation and Characterization

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To our knowledge, there is presently no pharmaceutical product on the market based on precipitation technology. There are a number of reasons, discussed in detail in Ref. (12). Briefly, the use of solvents creates additional costs. In addition, a prerequisite for precipitation is that the drug is at least soluble 24 Mu€ller et al. in one solvent, and this solvent needs to be miscible with a nonsolvent. Many of the newly developed compounds; however, are poorly soluble in aqueous and simultaneously in nonaqueous media, thus excluding this formulation approach.

Affinity of surfactant/stabilizer to the crystal surface) but also on the physical principles (electrostatic vs. steric stabilization) and the route of administration. In general, steric stabilization is recommended as the first choice because it is less susceptible to electrolytes in the gut or blood. Electrolytes reduce the zeta potential and subsequently impair the physical stability, especially of ionic surfactants. , the combination of steric and electrostatic stabilization. There is a wide choice of various charged surfactants in case of drug nanocrystals for oral administration.

In general, even highly water-sensitive drugs can be reduced to drug nanocrystals, even stored in the form of an aqueous nanosuspension (drug nanocrystals dispersed in aqueous surfactant/stabilizer medium). , more than 99% of the drug was recovered intact (9). On the other hand, aqueous Paclitaxel solution degrades to an extent of 80% within 25 minutes (10). Drug nanocrystals can be produced by bottom-up or topdown technologies. , it is a classical precipitation process (11). To our knowledge, there is presently no pharmaceutical product on the market based on precipitation technology.

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