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By F. Bezanilla, S.-A. Seoh, D. Sigg, D. M. Papazian (auth.), Ramón Latorre, Juan Carlos Sáez (eds.)

Ion channels let us see nature in all its beauty, to listen to a Bach suite, to sniff the aroma of grandmother's cooking, and, during this regard, they placed us in touch with the exterior global. those ion channels are protein molecules positioned within the phone membrane. In complicated organisms, cells have to speak on the way to learn about their metabolic prestige and to behave in a coordinate demeanour. The latter can be complete via a category of ion channels in a position to pierce the lipid bilayer membranes of 2 adjoining cells. those intercellular channels are the useful subunits of hole junctions. for this reason, the publication is split in components: the 1st half is devoted to ion channels that glance to the exterior global, and the second one half is devoted to hole junctions chanced on at telephone interfaces. This booklet is predicated on a chain of symposia for a gathering on ion channels and hole junctions held in Santiago, Chile, on November 28-30, 1995. The booklet will be worthy to graduate scholars taking the 1st steps during this box in addition to a reference for the aficionado. the purpose of the assembly was once customarily to teach the impression of assorted sleek strategies, together with cellphone biology, molecular biology, biophysics, and molecular­ genetics recommendations within the research of those ubiquitous intrinsic membrane proteins. Molecular-genetics strategies paved the line to the manipulation of the channel­ forming molecules.

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1994. Mg2+ dependent inward rectification of ROMK1 potassium channels expressed in Xenopus oocytes. J. Physiol. 3:399-409. Papazian, D. , X. M. Shao, S. Seoh, A. F. Mock, Y. Huang, and D. H. Wainstock. 1995. Electrostatic interactions of S4 voltage sensor in Shaker K+ channel. Neuron. 14:1293-1301. Papazian, D. , L. C. Timpe, Y. N. Jan, and L. Y. Jan. 1991. Alteration of voltage-dependence of Shaker potassium channel by mutations in the 54 sequence. Nature. 349:305-310. Ruppersberg, J. , R Frank, O.

Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation. Biophys. J. 66, 10 11-1021. Catterall, W. A. (1986). Molecular properties of voltage-sensitive sodium channels. Annu. Rev. Biochem. 55,953-985. Molecular Origin of Voltage Dependence 17 Guy, H. , and Seetharamulu, P. (1986). Molecular model of the action potential sodium channel. Proc. Nat!. Acad. Sci. USA 83,508-512. Hodgkin, A. L. and Huxley, A. F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve.

The study of the statistical composition of these heterogeneous protein populations may lead to a better understanding of the mechanisms of synthesis, subunit association, and assembly of membrane proteins. RANDOM ASSOCIATION OF PROTEIN SUBUNITS When two almost identical and independent types of subunit are randomly mixed, in addition to the two almost identical homo-multimeric channels, a plethora ofhetero-multimeric channels carrying different subunit composition can be formed. The number and proportions of heteromeric populations depend on the n-meric nature of the channel protein assembled and can be predicted according to the 35 David Naranjo 36 binomial distribution.

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