Handbook of Multiple Myeloma by Mohamad Mohty, Jean-Luc Harousseau PDF

By Mohamad Mohty, Jean-Luc Harousseau

This guide is an in-depth and entire advisor to the pathophysiology, prognosis, staging, therapy and administration of sufferers with a number of myeloma. The instruction manual was once commissioned to handle an unmet want for a e-book of this type within the myeloma box and to supply busy healthcare pros with an informative and academic assessment of the present and rising remedy strategies for a number of myeloma. Myeloma is a kind of bone marrow melanoma coming up from plasma cells and is the second one most typical kind of bone marrow melanoma, yet represents simply 1% of all cancers. The motives of myeloma will not be absolutely understood however it is believed to be attributable to an interplay of either genetic and environmental components. This instruction manual discusses those concerns to boot the most recent advancements within the box and should be a useful resource of topical details for all healthcare pros with an curiosity in a number of myeloma.

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Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma. J Clin Oncol. 2013;31:4529-4535. 27 Paiva B, Almeida J, Pérez-Andrés M, et al. Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell-related disorders. Cytometry B Clin Cytom. 2010;78:239-252. 28 Paiva B, Vidriales MB, Cerveró J, et al. Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation.

Similarly, in the CALGB 100104 study, patients received either low-dose lenalidomide (n=231) or placebo (n=229). 001). 008) [31,32]. In both trials, lenalidomide was superior to the comparator arm in all pre-defined prognostic subgroups. Treatment was well tolerated. However, in both studies, an unexpected over-incidence of secondary malignancies (both solid tumours and hematologic malignancies) was described. The pathophysiology of these secondary malignancies remains to be elucidated. At present, long-term maintenance with lenalidomide cannot be recommended to all patients because the OS benefit is not yet widely established and because of the concerns about long-term safety.

N Engl J Med. 2006;355:2765-2770. 9 Kyle RA, Therneau TM, Rajkumar SV, et al. Long-term follow-up of IgM monoclonal gammopathy of undetermined significance. Blood. 2003;102:3759-3764. 10 Bladé J, Dimopoulos M, Rosiñol L, Rajkumar SV, Kyle RA. Smoldering (asymptomatic) multiple myeloma: current diagnostic criteria, new predictors of outcome, and follow-up recommendations. J Clin Oncol. 2010;28:690-697. 11 Fernández de Larrea C, Kyle RA, Durie BG, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group.

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