Download e-book for kindle: Handbook of Vitamins by Robert B. Rucker, John W. Suttie, Donald B. McCormick

By Robert B. Rucker, John W. Suttie, Donald B. McCormick

Univ. of California, Davis. whole resource of nutrition functionality summaries. Covers water and fat-soluble supplements, evaluate equipment for dietary deficiency, and the security of excessive degrees of nutrition use. For nutritionists, clinicians, and different healthcare pros. prior variation: c1991.

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A significant body of experimental data accord with the gradient hypothesis. On the other hand, many other observations do not, including the observation that the gene product of Sonic hedgehog induces the polarizing activity of the ZPA, independent of the presence of RA (85). Thus, the gradient hypothesis is not as attractive today as it was when first formulated (80,82,84). Nonetheless, retinoic acid, some of its metabolites, and its receptors clearly play crucial roles in development (79,80,82,83).

Conversely, the addition of vitamin A to vitamin A–deficient keratinizing cells in tissue culture induces a shift to mucus-producing cells. Retinoids also rapidly induce F-9 teratocarcinoma cells, as well as many other cell lines, to differentiate. In this process, many new proteins appear in the newly differentiated cells. Thus, vitamin A and its analogs, both in vivo and in vitro, markedly influence the way in which cells differentiate (30,39). The mechanism by which retinoids induce cellular differentiation is becoming clear (Fig.

Phagocytosis, particularly the ‘‘oxygen burst’’ following the ingestion of a foreign body, and IgA secretion are also depressed in vitamin A deficiency (81). The synthesis of goblet cell mucins is reduced as well by vitamin A depletion, both in the intestinal mucosa and in the conjunctiva of the eye. Because protein malnutrition also adversely affects the immune response, children afflicted with both deficiencies are clearly at increased risk of developing severe infections (39). In vitamin A–sufficient animals, carotenoids also enhance the immune response.

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