By Dan Longo
The authority of Harrison's in a convenient, full-color paperback dedicated completely to Hematology and Oncology A Doody's center name for 2011! that includes the chapters on Hematology and Oncology that seem within the landmark Harrison's ideas of inner drugs, 17e, this compact medical spouse promises the entire most recent wisdom within the box, subsidized via the clinical rigor and reliability that experience outlined Harrison's. you can find insurance that displays the services of popular editors and individuals -- offered in a carry-anywhere layout that makes it perfect for the school room, the wards, or the purpose of care. With its ease of use, crucial diagnosis-speeding guidance, and acclaimed state of the art concepts, Harrison's Hematology and Oncology is a needs to for college students and clinicians alike. Harrison's Hematology and Oncology grants: a distinct single-source reference that includes hard-to-find built-in details on hematology and oncology Integration of pathophysiology with scientific administration subject matters in all the disease-oriented chapters invaluable content material in print shape from the acclaimed Harrison's 17e DVD fifty two chapters written by way of physicians who've made seminal contributions of their components of craftsmanship a hundred and fifteen high-yield self-assessment Q&A for examination and board overview, drawn from Harrison's ideas of inner medication Self-Assessment and Board overview, 17e entire assurance of need-to-know hematology and oncology issues, together with the most recent info on hematopoiesis, melanoma cellphone biology, and melanoma prevention precious appendix that highlights laboratory values of medical significance every little thing you will count on from Harrison's adapted for your forte Condensed desk of Contents: The mobile foundation of Hematopoiesis; Cardinal Manifestations of Hematologic affliction; Anemias; Myeloproliferative issues; Hematologic Malignancies; problems of Hemostasis; Biology of melanoma; rules of melanoma Prevention and remedy; Neoplastic issues; Endocrine Neoplasia; distant results of melanoma; Oncologic Emergencies and overdue problems. The Harrison’s uniqueness sequence is written by way of a similar world-renowned writer group who introduced you Harrison’s ideas of inner medication, 17e: Anthony S. Fauci, MD; Eugene Braunwald, MD; Dennis L. Kasper, MD; Stephen L. Hauser, MD; Dan L. Longo, MD; J. Larry Jameson, MD, PhD; Joseph Loscalzo, MD, PhD
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Extra info for Harrison's Hematology and Oncology (Harrison's Specialties)
Platelet count E. Cell morphology 1. Cell size 2. Hemoglobin content 3. Anisocytosis 4. Poikilocytosis 5. Polychromasia 13 CHANGES IN NORMAL HEMOGLOBIN/HEMATOCRIT VALUES WITH AGE AND PREGNANCY 14 SECTION II Cardinal Manifestations of Hematologic Disease FIGURE 2-3 Normal blood smear (Wright stain). High-power ﬁeld showing normal red cells, a neutrophil, and a few platelets. ) FIGURE 2-4 Severe iron-deﬁciency anemia. Microcytic and hypochromic red cells smaller than the nucleus of a lymphocyte associated with marked variation in size (anisocytosis) and shape (poikilocytosis).
Patients with normal O2 saturation who do not smoke either have an abnormal hemoglobin that does not deliver O2 to the tissues (evaluated by finding elevated O2hemoglobin afﬁnity) or have a source of EPO production that is not responding to the normal feedback inhibition. Further workup is dictated by the differential diagnosis of EPO-producing neoplasms. Hepatoma, uterine leiomyoma, and renal cancer or cysts are all detectable with abdominopelvic CT scans. Cerebellar hemangiomas may produce EPO, but they nearly always present with localizing neurologic signs and symptoms rather than polycythemiarelated symptoms.
22 Platelet Plug Formation . . . . . . . . . . . . . . . 22 Fibrin Clot Formation . . . . . . . . . . . . . . . . 23 Antithrombotic Mechanisms . . . . . . . . . . . . . 24 The Fibrinolytic System . . . . . . . . . . . . . . . 25 ■ Further Readings . . . . . . . . . . . . . . . . . 31 facilitated by direct binding to subendothelial collagen through speciﬁc platelet membrane collagen receptors. Platelet adhesion results in subsequent platelet activation and aggregation.