By Michael Boyiadzis, James Frame, David R. Kohler, Tito Fojo
The crucial treatment advisor to melanoma, Hematologic issues, and Supportive Care--Updated with the newest remedy Regimens
More than 500 therapy regimens
Hematology-Oncology Therapy, moment variation is an up to date, entire treatment consultant that promises greater than 500 remedy regimens in a succinct, uniform demeanour. the original tabular layout permits you to immediately find and enforce the correct remedy routine. Supported through the most recent perform directions, peer-reviewed literature, and the opinion of specialists, Hematology-Oncology Therapy integrates vast info that's severe to either place of work- and hospital-based perform of hematology and oncology.
Hematology-Oncology remedy is split into 3 sections:
offers unique information regarding the management, supportive care, toxicity, dose amendment, tracking, and efficacy of commonplace and lately authorized chemotherapeutic regimens, medicinal drugs, and organic brokers
Supportive Care, Drug coaching, problems, and Screening:
includes themes generally encountered in medical hematology-oncology perform, reminiscent of chemotherapy-induced nausea, oncologic emergencies, radiation issues, melanoma discomfort administration, melanoma screening, and lots more and plenty extra
Selected Hematologic Diseases:
gives you an authoritative consultant to remedy for the critical illnesses in consultative hematology
This version of Hematology-Oncology Therapy is enriched through the updating of all chapters in addition to the addition of a number of new chapters; the hot "Expert Opinion," which supplies ideas and suggestions from specialists at the use of remedy regimens; and inclusion of the most recent regimens.
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Additional info for Hematology - Oncology Therapy
Patients with unresectable tumor without obvious metastatic disease and without jaundice may beneﬁt from a regimen of ﬂuorouracil- or capecitabine-based chemotherapy Ϯ radiation. Metastatic disease is typically treated with systemic chemotherapy. Interventional procedures including brachytherapy and photodynamic therapy represent a therapeutic option for selected patients. However, overall survival of such patients remains poor (Razumilava and Gores, 2013) Less than 20% of all patients have disease that is deemed resectable, and even after having undergone potential curative resection, recurrence rates are high.
66 mL/s) Hold cisplatin Clinically signiﬁcant ototoxicity Discontinue cisplatin Clinically signiﬁcant sensory loss Discontinue cisplatin Notes: • Ten patients received further local treatment • Carboplatin used instead of cisplatin in the event of renal toxicity Supportive Care Antiemetic prophylaxis Emetogenic potential on days with cisplatin is HIGH. Potential for delayed symptoms Emetogenic potential on days with ﬂuorouracil alone is LOW See Chapter 39 for antiemetic recommendations Hematopoietic growth factor (CSF) prophylaxis Primary prophylaxis is NOT indicated See Chapter 43 for more information Antimicrobial prophylaxis Risk of fever and neutropenia is LOW Antimicrobial primary prophylaxis to be considered: • Antibacterial—not indicated • Antifungal—not indicated • Antiviral—not indicated unless patient previously had an episode of HSV See Chapter 47 for more information Diarrhea management Latent or delayed onset diarrhea*: Loperamide 4 mg orally initially after the ﬁrst loose or liquid stool, then Loperamide 2 mg orally every 2 hours during waking hours, plus Loperamide 4 mg orally every 4 hours during hours of sleep • Continue for at least 12 hours after diarrhea resolves • Recurrent diarrhea after a 12-hour diarrhea-free interval is treated as a new episode • Rehydrate orally with ﬂuids and electrolytes during a diarrheal episode • If a patient develops blood or mucus in stool, dehydration, or hemodynamic instability, or if diarrhea persists Ͼ48 hours despite loperamide, stop loperamide and hospitalize the patient for IV hydration (continued ) *Creatinine clearance is used as a measure of glomerular ﬁltration rate † This also applies to patients with creatinine clearance of 40–60 mL/min before commencing treatment Patient Population Studied Study of 19 patients (3 males, 16 females), median age 58 years, WHO performance status: G0-1 in 68% and G2 in 32%.
001). 001). Adverse events were similar in both groups, with the exception of neutropenia—higher in the cisplatin plus gemcitabine group—although the number of neutropenia-associated infections was similar in the 2 groups. Consequently, a cisplatin ϩ gemcitabine regimen has become the standard of care on this indication Novel agents, such as epidermal growth factor receptor blockers, MEK inhibitors and angiogenesis inhibitors, may hold promise for improving the therapeutic results obtained with conventional chemotherapy alone, but clinical study results are pending (Sasaki et al, 2013) Intrahepatic cholangiocarcinoma Patients who have undergone a tumor resection with or without ablation with negative margins may be followed up with observation, because there is no deﬁnitive adjuvant regimen to improve their overall survival.