By Menso J. Nubé, Muriel P.C. Grooteman, Peter J. Blankestijn
This e-book provides an entire description of on-line hemodiafiltration, in 5 sections. it really is special within the systematic and whole method within which hemodiafiltration is defined. each one bankruptcy is done through a point-to-point precis of crucial info, in a separate textual content field. a part of the publication is devoted to the theoretical history of convective clearance. during this half, questions of safety and qc is reviewed (especially at the caliber of water for dialysis and substitution fluid), in addition to gear (both dialyzers and machines) with which this remedy will be played. As lately the result of numerous randomized managed trials have been to be had, the impression of hemodiafiltration on tough medical finish issues (mortality and morbidity) is mentioned intimately. This has now not been performed prior to, because the most up-to-date book/journal on hemodiafiltration used to be released in 2011, earlier than the result of the three randomized managed trials have been released. additionally, the methodological caliber of the rigors is mentioned through knowledgeable, so as to aid the readers of their judgment of the rigors a part of the ebook concentrates at the influence of the therapy on numerous biomarkers and uremic pollutants. a number of clinically suitable concerns is mentioned individually, akin to the prescription of anticoagulation in the course of the remedy, drug prescription and clearance for sufferers taken care of with hemodiafiltration, and hemodynamic balance. eventually, a realistic advisor on how one can practice the therapy is equipped. during this distinctive part, likely uncomplicated yet very important information of hemodiafiltration-treatment is mentioned, akin to the significance of needle measurement for blood circulation premiums, the adaptation among filtration fraction and substitution ratio, different goals that may be set and the way to arrive them. As such a lot literature is principally interested by theoretical matters, this detailed function quite may also help the sector to accomplish hemodiafiltration, and solution sensible questions.
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Extra resources for Hemodiafiltration: Theory, Technology and Clinical Practice
2. Colton CK, Henderson LW, Ford CA, Lysaght MJ. Kinetics of hemodiafiltration. I. In vitro transport characteristics of a hollow-fiber blood ultrafilter. J Lab Clin Med. 1975;85:355–71. 3. Henderson LW, Colton CK, Ford CA. Kinetics of hemodiafiltration. II. Clinical characterization of a new blood cleansing modality. J Lab Clin Med. 1975;85:372–91. 4. Leber HW, Wizemann V, Goubeaud G, Rawer P, Schutterle G. Hemodiafiltration: a new alternative to hemofiltration and conventional hemodialysis. Artif Organs.
Since the UF and backfiltration times are much shorter in PP-HDF than the time for blood to pass through the dialyzer, blood is concentrated and diluted many times before it leaves the dialyzer. High removal rate of middle molecules and reduction of symptoms of dialysis-related amyloidosis have been reported with this technique [72, 73]. Double High-Flux Hemodiafiltration (DHF-HDF) This technique was designed in the beginning of 1980s in order to achieve a drastic reduction of treatment time over conventional HD and increase convective transport without the need for ultrapure substitution fluid and consequently dedicated machines.
Ok E, Asci G, Toz H, Ok ES, Kircelli F, Yilmaz M, Hur E, Demirci MS, Demirci C, Duman S, Basci A, Adam SM, Isik IO, Zengin M, Suleymanlar G, Yilmaz ME, Ozkahya M, Turkish Online Haemodiafiltration Study. Mortality and cardiovascular events in online haemodiafiltration (OL-HDF) compared with high-flux dialysis: results from the Turkish OL-HDF Study. Nephrol Dial Transplant. 2013;28(1):192–202. 95. Penne EL, van der Weerd NC, Bots ML, van den Dorpel MA, Grooteman MP, Lévesque R, Nubé MJ, Ter Wee PM, Blankestijn PJ, CONTRAST investigators.