By Bandar Al Knawy, K. Rajender Reddy, Luigi Bolondi
A vital source for gastroenterologists, hepatologists, liver surgeons, hepatobiliary surgeons, oncologists, and all these operating within the box of hepatocellular carcinoma (HCC), Hepatocellular Carcinoma: a realistic method covers the updates and up to date advancements at the prognosis, screening, and entire scientific and surgical administration of HCC. This extraordinary textbook explores all points of the affliction utilizing a pragmatic, evidence-based method, and offers step by step therapy guidance which are acceptable to all medical situations. Highlights within the textual content contain: screening and surveillance easy methods to reduction within the prevention of HCC imaging applied sciences for exact analysis, together with ultrasound and puppy remedy modalities for HCC, similar to neighborhood ablation treatment, chemoembolization, chemotherapy, and liver resection and transplantation a dialogue on novel treatments and destiny healing developments for treating HCC
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An important source for gastroenterologists, hepatologists, liver surgeons, hepatobiliary surgeons, oncologists, and all these operating within the box of hepatocellular carcinoma (HCC), Hepatocellular Carcinoma: a pragmatic method covers the updates and up to date advancements at the analysis, screening, and complete scientific and surgical administration of HCC.
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Additional info for Hepatocellular Carcinoma: A Practical Approach
Achkar JP, Araya V, Baron RL, et al. Undetected hepatocellular carcinoma: clinical features and outcome after liver transplantation. Liver Transpl Surg 1998; 4:477–482. Screening and Surveillance 35 48. de Ledinghen V, Laharie D, Lecesne R, et al. Detection of nodules in liver cirrhosis: spiral computed tomography or magnetic resonance imaging? A prospective study of 88 nodules in 34 patients. Eur J Gastroenterol Hepatol 2002; 14:159–165. 49. Libbrecht L, Bielen D, Verslype C, et al. Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations.
Moreover, specificity and sensitivity inevitably vary depending on the cut-off level chosen for the diagnosis. An intrinsic disadvantage of AFP as a tumor marker is the fact that serum level of AFP can increase in patients without HCC when hepatitis is active, partly because of accelerated cellular proliferation in regeneration. The value of 20 ng/mL is often adopted as the upper limit of normal range of AFP because serum AFP level rarely exceeds this level in healthy subjects. However, values slightly above this level are hardly diagnostic of HCC among patients with chronic hepatitis, and adopting a low cut-off value would result in an inappropriately low specificity.
Clin Gastroenterol Hepatol 2005; 3:S141–S143. 22. Tanaka K, Hirohata T, Takeshita S, et al. Hepatitis B virus, cigarette smoking and alcohol consumption in the development of hepatocellular carcinoma: a case-control study in Fukuoka, Japan. Int J Cancer 1992; 51:509–514. 23. Donato F, Tagger A, Gelatti U, et al. Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 2002; 155:323–331. 24. Kuper H, Tzonou A, Kaklamani E, et al.