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By Earl T. Engle

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Extra resources for Hormones and the Aging Process. Proceedings of a Conference Held at Arden House, Harriman, New York, 1955

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Hr. 154 Normal produc. , 70-kg. man, mg. M. level) Maximal produc. , 70-kg. man, mg. 1 202 163 EFFECT OF AGING ON THE STEROID METABOLISM 25 that either certain tissues concentrate the excess Cortisol or that it is rapidly converted into an equilibrium mixture with some free molecule which does not give the Porter-Silber reaction, and that it is the removal of the mixture which is being measured. 6 /Ag. per 100 ml. 3 jug. per kilogram per hour would be required. This would mean that the adrenals of a 70-kg.

Old people take a drink and they go to sleep. Hyperthyroidism is analogous and they may look almost as though they had Addison's disease. The internal secretions largely work on intermediarly metabolism. W h y should an old person be fatigued? Well, I put this question: Is it possible that the synthesis of high-energy phosphate and sulfur compounds is depleted in the aged and that though you have hyperthyroidism, in­ stead of having more vigorous muscles and tissues, one has only those that are worn out because they cannot synthesize the proper amount of energy?

Lab. Clin. Med. 42, 1 1 6 . Tyler, F . , Sandberg, A. , Florentin, Α. , and Samuels, L . Τ. 1955. / . Am. Geriatrics Soc. 3, 7 9 . DISCUSSION DR. WHITE: Is this correct for disposal as well as distribution? D R . S A M U E L S : W e are working in an area where the normal curve is fairly flat. W e assume then that at these normal levels, removal and production are at equilibrium. DR. WHITE: I see. D R . S A M U E L S : And the removal is the logarithmic value at this point, so apply­ ing our correction for distribution area we can calculate the rate of production that would be involved to maintain this amount of destruction.

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