New PDF release: Human Blood Plasma Proteins: Structure and Function

By Johann Schaller, Simon Gerber, Urs Kaempfer, Sofia Lejon, Christian Trachsel

The advertisements indicated this could be a publication with loads of information regarding all of the proteins in human plasma. It really has little or no details that's priceless. every one protein has a categorization into the kind of protein (immune method, delivery, and so on) and a quick description (this protein transports x) and, frequently, a ribbon diagram of the constitution. There are typically or 3 literature references.

For $170, I anticipated even more.

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Additional resources for Human Blood Plasma Proteins: Structure and Function

Sample text

B) Top view. 14(b). The YWTD repeats form a six-bladed b-propeller tightly packed against the C-terminal EGF-like domain. The structure of the extracellular domain of the low-density lipoprotein receptor was determined by X-ray diffraction (for details see Chapter 12). 13 THE C-TERMINAL CYSTINE KNOT (CTCK) STRUCTURE Several growth factors like the transforming growth factor TGF-b, the nerve growth factor NGF and the platelet-derived growth factor PDGF as well as the gonadotropins follitropin b-chain and lutropin b-chain contain a so-called cystine knot structure (for details see Chapters 13 and 14).

12. The 3D structure of the VWFA domain linked to the catalytic chain in complement factor B was determined by X-ray diffraction (PDB: 1RRK) (for details see Chapter 8). The domain adopts the dinucleotide binding or a/b ‘Rossmann’ fold characterised by a central b-sheet surrounded by ahelices. The VWFA domain 1 is the principal binding site for glycoprotein Ib (GPIb) and the VWFA domains bind to collagen and heparin. The inter-alpha-trypsin inhibitor heavy chains H1, H2, H3 and H4 each contain one VWFA domain.

Lawler and Hynes, 1986, The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins, J. Cell. , 103, 1635–1648. , 1992, Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein, Science, 258, 987–991. , 1999, Solution structure and dynamics of the plasminogen kringle 2–AMCHA complex: 3(1)–helix in homologous domains, Biochemistry, 38, 15741–15755. , 1999, Crystal structure of the membrane-binding C2 domain of human coagulation factor V, Nature, 402, 434–439.

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