By Sergej M., M.D., Ph.D. Ostojic
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Additional resources for Human Health and Nutrition : New Research
Intervention Running, maximal field test Cycling, maximal ̇ O2max test Running, progressive exercise test till fatigue Running at 80-90% ̇ O2max for 30 min Step test, 40 min Plasma zinc concentration Immediately During after exercise exercise recovery NS Decreased at 120 min Increased Not reported Decreased Not reported Increased Decreased at 30 min Not reported Decreased Swimming, 400 m Increased Boxing training, 60 min Decreased Decreased at 60 min Not reported 36 Anna Chu, Meika Foster and Samir Samman Figure 4.
In recovery from exercise, the initial stages of muscle repair occur with monocytes and leukocytes infiltrating muscle cells, initiating cytokine production and stimulating the subsequent inflammatory response . Inflammatory cytokines have been shown to regulate the expression of cellular zinc transporters in a number of tissues and thereby alter whole body zinc homeostasis . Biomarkers of Zinc Status Systemic zinc concentration, analyzed in serum or plasma, is currently the recommended biomarker when assessing zinc status within a population [38, 39].
A lack of human studies limits the translation of GPR39 functions to whole body zinc homeostasis. Metallothionein MT represents a large group of metal-binding proteins which have been shown to buffer cytoplasmic zinc concentration. In humans, multiple isoforms of MT have been found, of which only those in the MT-1 and MT-2 subtypes are central to mediating cellular zinc homeostasis . Structurally, MT is defined by the unique amino acid sequence of cysteine residues that provide binding sites for metals, such as zinc.