Read e-book online Leukemias: Principles and Practice of Therapy PDF

By Stefan Faderl, Hagop Kantarjian

Edited via specialists from one of many world’s biggest leukemia facilities, this ebook offers details at the biology of the range of leukemic problems, updated diagnostic trying out and plenty of new advancements in remedy. Chapters overlaying new remedies current an outlook for the longer term and clarify the reason for ongoing medical trials.

Topics include:

  • Targeted treatment, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, package inhibitors, BCR-ABL inhibitors)
  • Ras inhibitors
  • Epigenetic treatment (hypomethylaters and histone deacetylase inhibitors)
  • Lenalidomide analogs
  • New chemotherapy medicines, e.g. clofarabine, cloretazine, sapacitabine, forodesine
  • Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols together with dasatinib or imatinib)
  • New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40)
  • Thrombopoietic agents

Leukemias: rules and perform of Therapy

  • Includes useful details to steer you in difficult events, akin to therapy of aged sufferers, being pregnant, relapsed and refractory disease
  • Incorporates chapters on supportive care and pharmacologic information regarding the main often used medicinal drugs during this area

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Extra info for Leukemias: Principles and Practice of Therapy

Example text

78 Askling J, Brandt L, Lapidus A, et al. Risk of haematopoietic cancer in patients with inflammatory bowel disease. Gut 2005;54:617–22. 79 Ross JA, Kasum CM, Davies SM, Jacobs DR, Folsom AR, Potter JD. Diet and risk of leukemia in the Iowa Women’s Health Study. Cancer Epidemiol Biomarkers Prev 2002;11:777–81. 80 Hursting SD, Margolin BH, Switzer BR. Diet and human leukemia—an analysis of international data. Preventive Medicine 1993;22:409–22. 81 Kane EV, Roman E, Cartwright R, Parker J, Morgan G.

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Cancer Causes Control 2007;18:457–78. 142 Berger U, Maywald O, Pfirrmann M, et al. Gender aspects in chronic myeloid leukemia: long-term results from randomized studies. Leukemia 2005;19:984–9. 143 Moloney WC. Radiogenic leukemia revisited. Blood 1987;70: 905–8. 144 Corso A, Lazzarino M, Morra E, et al. Chronic myelogenous leukemia and exposure to ionizing radiation–a retrospective study of 443 patients. Ann Hematol 1995;70:79–82. 145 Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS.

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