By G. Matheis, A. Moritz, M. Scholz
The idea that of leukocyte depletion has been said as a compulsory method in transfusion medication for your time. inside fresh years, leukocyte elimination filters have additionally develop into a a growing number of vital instrument in cardiac surgical procedure, the place this method is a logical technique to restrict neutrophil-mediated problems. The complicated biology of neutrophils for that reason represents a tremendous focal point of this quantity. various scientific settings and the corresponding leukocyte filtration tools are one other subject of debate, together with transfusion, transplantation, perfusion and filtration modalities, blood cardioplegia in addition to destiny filtration thoughts akin to bioactive cytokine filters. Aiming to supply an summary of the event with experimental and medical leukocyte filtration and of the cutting-edge in scientific software, this booklet additionally provides an outlook at the attainable destiny function of leukocyte depletion in cardiac surgical procedure and cardiology.
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Additional info for Leukocyte Depletion in Cardiac Surgery and Cardiology
Especially, the mechanisms of ‘immunomodulation’, as reflected by the term itself, have been rather elusive. However, postoperative complications, including pneumonia and death, as well as reduced durations of hospital stays, have been found to be decreased in patients undergoing gastrointestinal surgery . However, more investigations will be necessary to better understand the reasons for these effects. CMV Transmission. Random platelet concentrates result in an up to 4% transmission of CMV despite testing .
Manara FS, Schneider DL: The activation of the human neutrophil respiratory burst occurs only at temperatures above 17°C: Evidence that activation requires membrane fusion. Biochem Biophys Res Commun 1985;132:696–701. Swank RL: Alteration of blood on storage: Measurement of adhesiveness of ageing platelets and leukocytes and their removal by filtration. N Engl J Med 1961;265:728. Truter EJ, Murray PW: Morphological classification by scanning electron microscopy of erythrocytes stored at 4°C in citrate-phosphate-dextrose anticoagulant.
Matheis G, Scholz M, Gerber J, Abdel-Rahman U, Wimmer-Greinecker G, Moritz A: Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injury. Perfusion 2001;16:43– 49. Mechanisms and Technical Aspects of Leukocyte Depletion 31 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 Sheppard SV: Are the occasional high pressure gradients associated with leucocyte-reducing filters and oxygenators a similar phenomenon? Perfusionist 2000;24(3):7–10. Sheppard SV, Huxtable S, Smith DC, Gibbs RV: Does the use of aggressive blood cooling during CPB cause fibrin precipitation?