Lymphocyte Trafficking in Health and Disease by Raffaele Badolato, Silvano Sozzani PDF

By Raffaele Badolato, Silvano Sozzani

Since the invention of chemokines and of chemokine receptors it has turn into glaring that expression of chemokines on the website of irritation might control the composition of mobile infiltrate, thereby directing the kind of immune reaction. lately, the molecular characterization of inherited issues of immune process, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), that are characterised by means of cytoskeleton/adhesion defects or by way of altered reaction of chemokine receptors has contributed to clarifying the main avid gamers of immune reaction in common body structure and in sickness. This ebook, which bargains with the outline of the function of chemokines in immune reaction and underlines capability ambitions of therapeutical intervention, deals a chain of contributions of the main difficult points of lymphocyte migration in homeostasis and in disease.

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Extra resources for Lymphocyte Trafficking in Health and Disease

Example text

Lymphocyte tissue-specific vascular recognition and extravasation from blood into tissues relies on the functional interplay between adhesion molecules, expressed by lymphocytes and endothelial cells, and chemoattractants, presented by the endothelial cells to rolling lymphocytes [1–3]. Numerous molecular components of this system have been identified and their mode of action investigated in detail at molecular level (see next sections). Leukocyte vascular recognition is commonly described to involve three steps, each mediated by a distinct protein family (Fig.

Accurate studies have shown that chemokines can trigger full integrin activation and dependent lymphocyte arrest under flow within a few milliseconds [27]. De facto, chemokines are considered the most powerful physiological integrin activators. However, what does “full integrin activation” mean? The capability of lymphocytes to modulate their own adhesiveness for a substrate by changing integrin avidity for the ligand was established a long time ago [28]. On the other hand, it was only recently that the modality of integrin activation induced by chemokines and responsible for almost all immediate lymphocyte arrest under flow was definitively identified.

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