Read e-book online mTOR Inhibition for Cancer Therapy: Past, Present and Future PDF

By Monica Mita, Alain Mita, Eric K. Rowinsky

This ebook describes the demanding situations all in favour of constructing mTOR inhibitors for melanoma remedy, beginning with an in-depth exam in their molecular mechanism of motion, with emphasis at the classification side-effects, efficacy and mechanisms of resistance, in addition to on promising novel instructions for his or her improvement, together with novel compounds and rational mixtures with different anti-neoplastic medicines.

Over the final 10 years, inhibitors of mTOR have emerged as an immense type of anticancer medicines. rapamycin analogs are at the moment authorized for the therapy of renal phone carcinoma, and it really is anticipated number of different tumor varieties may gain advantage from mTOR inhibition, with a variety of scientific trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have additionally proven promise when it comes to their stronger tolerability and efficacy and are present process large scientific evaluate, with an anticipated 30+ compounds at the moment lower than review.

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Read Online or Download mTOR Inhibition for Cancer Therapy: Past, Present and Future PDF

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Additional info for mTOR Inhibition for Cancer Therapy: Past, Present and Future

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82. Wells V, Downward J, Mallucci L. Functional inhibition of PI3K by the betaGBP molecule suppresses Ras-MAPK signalling to block cell proliferation. Oncogene. 2007;26(55):7709–14. 83. Wennstrom S, Downward J. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Mol Cell Biol. 1999;19(6):4279–88. 84. Dibble CC, Asara JM, Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.

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157. Brugarolas JB, et al. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 2003;4(2):147–58. 158. Duvel K, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010;39(2):171–83. 159. Hudson CC, et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002;22(20):7004–14. 160. Laughner E, et al. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.

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