New PDF release: Maimonide

By Mauro Zonta

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It is convenient to pool a few units in a large syringe or a transfer pack before transfusion. It is advisable to use an inline filter during transfusion, to remove insoluble debris. It is not necessary to cross-match cryoprecipitate, but it is preferable to use cryoprecipitate of compatible blood group. Cryoprecipitate prepared from group 0 plasma may cause haemolysis if transfused to group A or group B patients. The dose of cryoprecipitate for treatment of haemophilia A or von Willebrand disease depends on the patient's body weight, the severity of the disease and the clinical situation.

Dextran occasionally causes febrile transfusion reaction and anaphylactic reaction. It may also occasionally precipitate renal failure. The use of plasma substitutes results in dilution of the patient's clotting factors, particularly when they are already deficient. In addition to the dilution effect, low molecular weight dextran can promote oozing from wounds by acting directly on capillary circulation. Plasma substitutes, like all other plasma volume expanders, can cause circulatory overload.

Such large doses may be very painful if given intramuscularly, and subcutaneous infusion may be used instead. HUMAN NORMAL IMMUNOGLOBULIN: INTRA VENOUS Description Like the intramuscular preparation, this is made by fractionating plasma collected from a large number of donors, and there are considerable variations between batches and preparations in specific antibody content. This preparation is free from immunoglobulin aggregates and is available in either clear liquid or lyophilised form. Each vial usually contains 1, 3 or 5 g of IgG.

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