By Reinhold Munker, Erhard Hiller, Jonathan Glass, Ronald Paquette
Now in its moment version, sleek Hematology: Biology and scientific administration displays the most important advances within the figuring out, analysis, and therapy of blood issues. It describes the most recent medical and clinical advancements in addition to info exact and molecular cures. The e-book brings jointly evidence, suggestions, and protocols very important for the perform of hematology. In 23 chapters, all significant blood illnesses are lined, in addition to infrequent ailments which are of medical curiosity. As within the prior version, every one bankruptcy is illustrated by way of tables, figures, and a variety of colour plates.
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Extra info for Modern Hematology: Biology and Clinical Management (Contemporary Hematology)
The immunological and antiviral effects of IFN-γ are different from those of the type I IFNs. IFN-γ activates monocytes and macrophages, leads to an increase in the expression of Fc receptors, augments the production of superoxide, and enhances phagocytosis and bactericidal capacity. It increases the cytotoxicity of NK cells and the immunoglobulin synthesis of B-lymphocytes. Like IFN-α, IFN-γ inhibits the growth of some tumor cells in vitro and enhances the cell surface expression of numerous antigens including class I and class II histocompatibility antigens.
1. Cytogenetics The study of chromosomes, or cytogenetics, aids in the diagnosis of many human tumors and is a common method used to establish the clonality of abnormal cells found in the bone marrow, the peripheral blood, or any other tissue. The normal human somatic cell is diploid, meaning that each of the 22 chromosomes is present in two copies. In addition, the sex chromosomes, XX in females and XY in males, are present in all somatic cells. The cells of sperm or oocytes that have 23 single chromosomes are haploid.
5–3 mL) are gently aspirated. A bone marrow aspiration yields samples for cytomorphology, cytogenetics, surface markers, and molecular studies. In some chronic infections, bone marrow cultures are also indicated. For the optimal morphological evaluation, ethylenediamine tetraacetic acid (EDTA) is used as an anticoagulant; for other studies like cytogenetics or surface markers, heparin is used. A bone marrow aspiration provides information about the state of maturation and the proliferation of the three hematopoietic lineages (erythropoiesis, myelopoiesis, and thrombopoiesis).