's Molecular Hematology, Second Edition PDF

Content material:
Chapter 1 Beginnings: The Molecular Pathology of Hemoglobin (pages 1–17): David Weatherall
Chapter 2 Molecular Cytogenetics (pages 18–24): Debra M Lillington, Silvana Debernardi and Bryan D Young
Chapter three Stem Cells (pages 25–40): Eyal C Attar and David T Scadden
Chapter four The Genetics of Acute Myeloid Leukemias (pages 41–46): D Gary Gilliland
Chapter five Secondary Myelodysplasia/Acute Myelogenous Leukemia ? evaluate of probability (pages 47–52): D Gary Gilliland and John G Gribben
Chapter 6 Detection of minimum Residual sickness in Hematological Malignancies (pages 53–71): Drew Provan and John G Gribben
Chapter 7 continual Myeloid Leukemia (pages 72–81): Brian J Druker
Chapter eight Myelodysplastic Syndromes (pages 82–89): Jaqueline Boultwood and James S Wainscoat
Chapter nine Myeloproliferative problems (pages 90–104): Anthony J Bench, George S Vassiliou, Brian J P Huntly and Anthony R Green
Chapter 10 Lymphoid Neoplasms (pages 105–114): Anthony G Letai and John G Gribben
Chapter eleven The Molecular Biology of a number of Myeloma (pages 115–124): P Leif Bergsagel
Chapter 12 The Molecular foundation of Anemia (pages 125–149): Lucio Luzzatto and Anastasios Karadimitris
Chapter thirteen The Molecular foundation of Iron Metabolism (pages 150–158): Nancy C Andrews
Chapter 14 Hemoglobinopathies because of Structural Mutations (pages 159–172): Ronald L Nagel
Chapter 15 Molecular Coagulation and Thrombophilia (pages 173–183): Bjorn Dahlback and Andreas Hillarp
Chapter sixteen The Molecular foundation of Hemophilia (pages 184–198): Paul L F Giangrande
Chapter 17 The Molecular foundation of Von Willebrand disorder (pages 199–209): Luciano Baronciani and Pier Mannuccio Mannucci
Chapter 18 Platelet issues (pages 210–224): Katherine A Downes and Keith R McCrae
Chapter 19 The Molecular foundation of Blood cellphone Alloantigens (pages 225–240): Willem H Ouwehand and Cristina Navarrete
Chapter 20 capabilities of Blood crew Antigens (pages 241–250): John R Pawloski and Marilyn J Telen
Chapter 21 Autoimmune Hematological problems (pages 251–266): Drew Provan, James B Bussel and Adrian C Newland
Chapter 22 Hematopoietic progress elements (pages 267–279): Graham Molineux
Chapter 23 Molecular Therapeutics in Hematology (pages 280–297): A Keith Stewart and Jeffrey A Medin
Chapter 24 Gene Expression Profiling within the learn of Lymphoid Malignancies (pages 298–306): Ulf Klein and Riccardo Dalla?Favera

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Extra resources for Molecular Hematology, Second Edition

Sample text

Members of this family include TNFR1, TNFR2, fas, CD40, nerve growth factor (NGF) receptor, CD27, CD30 and OX40, each with at least one distinct biological effect. Components of the hematopoietic microenvironmental niche While soluble factors influence stem cell fate, these factors are seen by the cell in the context of cell–cell contact among heterologous cell types and cell–matrix contact, which make up the three-dimensional setting of the bone marrow. What actually constitutes the critical microenvironment for hematopoiesis is surprisingly poorly defined.

Members of this family have a profound inhibitory effect on the growth and differentiation of hematopoietic cells and on auxiliary hematopoietic cells. Binding of TFG-β requires TbRII. After binding, signal transduction occurs via activation of serine–threonine kinase cytoplasmic domains of the receptor chains, which results in the phosphorylation of Smad molecules on serines. Phosphorylated Smad complexes translocate to the nucleus, where they induce or repress gene transcription. TGF-β is the best characterized negative regulator of hematopoiesis.

This technique is known as ‘comparative genomic hybridization’ (CGH) and in turn has led to the very recent technique of array CGH. Array CGH promises to provide much higher resolution of genomic imbalance compared with chromosome-based CGH. Currently, custom-designed arrays containing oncogenes and tumor suppressor genes are available commercially and arrays with DNA clones spaced at 1 Mb intervals throughout the genome are becoming available. Gene expression profiling also offers exciting prospects in hematology and, coupled with the molecular cytogenetic and cytogenetic information, accurate diagnostic genetic analysis looks set to revolutionize patient management.

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