New PDF release: Neurohormones and Neurohumors: Structure and Function of

By Prof. Berta Scharrer (auth.), J. Ariëns Kappers (eds.)

Having authorized the duty to prepare, in Amsterdam, a global Congress in behalf of the foreign Sodety for Neurovegetati'V'e learn akin to is held each moment 12 months, it happened to me that it would be worthy­ whereas to alter its ordinary trend a bit of. rather than giving purely the chance for l'eading a nurnber of quite brief loose papers, kind of grouped in lots of different types, we determined first of all a symposium on a unique subject 'to be handled from a number of features via a numbe·r of invited audio system, the final day of the congress being basically on hand for brief loose communications. The significant subject for the symposium ultimately selected used to be "Neurohormones and N eurohumors" as this topic is of curiosity :to many morphologists, physiologists, pharmacologists, neuro-endocrinologists, biochemists and clini­ cians, and belongs to a speedily increasing Held of study. additionally, it seemed to us that there's a few confusion in regards to the defini­ tion of those phrases which aren't seLdom used indifferently. I was hoping that this sort of symposium could give a contribution 1to a clearer apprehension of the phrases in accordance with morphological, physiological and biochemical standards in addition to to a clearer realizing of a few difficulties concerned with a view to must be topics of destiny investigations.

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Or by means of histochemical re actions such as those revealing either sulfhydril or disulfide Fig. 7. Granule formation in Golgi structures (G) which consist of dilated cavities and flatt ened sacs giving rise to numerous vesicles which, by an increase of their size and electron density, reach the aspect of large elementary granules, here :2000 A in diameter. NS , Nissl-suhstance in an "active" state with dilated e rgastoplasmic cisternae (compare with Fig. 3). MV, multivesicular bodies. groups (Barrnett, 1954; Sloper, 1955; Adams and Sloper, 1955, 1956; Howe and Pearse, 1956; Gabe, 1955, 1960), or glucids in very variable amounts, or perhaps lipids as stated by Schiebler (1951, 1952) and Bachrach and coli.

3). MV, multivesicular bodies. groups (Barrnett, 1954; Sloper, 1955; Adams and Sloper, 1955, 1956; Howe and Pearse, 1956; Gabe, 1955, 1960), or glucids in very variable amounts, or perhaps lipids as stated by Schiebler (1951, 1952) and Bachrach and coli. (1953) , hut rather convincingly denied by Sloper (1955, 1966), and finally in any case proteins. b) Radio-isotopic labelling reveals incorporation of sulfur and migration of labelled neurosecretory material. c) With the electron microscope, we observe vesicles loaded with dense material (elementary granules) .

The synthesis of secreted material might partly occur progressively along the axon. It appears likely that hormones might be released not only at the ending, but also along the course of the axon. The nerve impulse conducted by the neurosecretory neuron itself is likely to be responsible for hormone release. The morphological and biochemical aspects of the mechanism of hormone release, for instance the part possibly played by acetylcholine, remain uncertain. There seems to be a conspicuous depletion of the dense content of granules.

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