New PDF release: New therapeutic agents in thrombosis and thrombolysis

By Jane E Freedman; Joseph Loscalzo

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Clearly, there is no consensus on how to balance these competing risks, particularly when these nonfatal endpoints are considered part of the same composite endpoint. Noninferiority Design An alternative to the use of a composite primary endpoint is a “noninferiority” trial design. , not inferior more than some small arbitrary quantity). Noninferiority trials are especially susceptible to bias and must be carefully designed and conducted. A strong rationale for using a noninferiority design should be provided, as a superiority design would otherwise almost always be preferable.

Role of intracellular signaling events in ADP-induced platelet aggregation. Thromb Haemost 1999; 82:1322–1326. 21. Daniel JL, Dangelmaier C, Jin J, et al. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 1998; 273:2024–2029. 22. Fagura MS, Dainty IA, McKay GD, et al. P2Y1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors. Br J Pharmacol 1998; 124:157–164. 23. Jin J, Kunapuli SP.

Clearly, there is no consensus on how to balance these competing risks, particularly when these nonfatal endpoints are considered part of the same composite endpoint. Noninferiority Design An alternative to the use of a composite primary endpoint is a “noninferiority” trial design. , not inferior more than some small arbitrary quantity). Noninferiority trials are especially susceptible to bias and must be carefully designed and conducted. A strong rationale for using a noninferiority design should be provided, as a superiority design would otherwise almost always be preferable.

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