Download PDF by Nilanjana Maulik, Gautam Maulik: Nutrition, Epigenetic Mechanisms, and Human Disease

By Nilanjana Maulik, Gautam Maulik

As foodstuff study is moving its concentration from epidemiology and body structure to results of foodstuff on the molecular point, a uniquely adapted vitamin that corresponds to the calls for of our genetic signature is rising as an vital want. utilizing high-throughput genomic instruments, nutrigenomics unravels the impression of micro- and macronutrients as effective nutritional signs regulating metabolic pathways and unmasks how weak genotypes are predisposed to diet-related illnesses.

Selected themes from this box were lined in a few books, yet no different accomplished textual content on epigenetics, nutrients, and human future health and illness is on the market, before. This e-book illustrates nutrition’s impact on epigenetic inheritance and the mechanisms underlying the amendment of the metabolic imprint of someone. This enriched knowing of nutrigenomics should be utilized to grasp a adapted nutrition which may alleviate imprinted metabolic syndromes. in particular, the e-book makes a speciality of:
<UL> * Maternal, perinatal, and neonatal nutrition
* Epigenetic mechanisms and cancer
* affects of nutritional elements, folate deficiency and DNA methylation
* Nutrition’s impression on genetic imprinting
* the fundamentals of nutrigenomics and epigenetic regulation


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Prades, B. Estour, and M. Peoc’h. 2005. Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Virchows Archiv 447 (1):18–23. , C. Allis, and E. Bernstein. 2007. Epigenetics: a landscape takes shape. Cell 128(4):635–38. Guarente, L. 2000. Sir2 links chromatin silencing, metabolism, and aging. Gene Dev 14(9):1021. , J. Zhang, I. Keshet, M. Bustin, and H. Cedar. 2003. The role of DNA methylation in setting up chromatin structure during development.

2005. Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging 26 (6):929–37. , D. Martin, and R. Ward. 2004. Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis 19 (2):95–101. , P. Pakneshan, and S. A. Rabbani. 2004. DNA methylation and breast cancer. Biochem Pharmacol 68 (6):1187–97. , and L. Guarente. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (6825): 227–30.

2003). In addition, several age-related studies revealed defects in stem cells that can limit proper organ maintenance and hence contribute to a shorter life span (Chambers et al. 2007). However, the possible role of stem cell aging in the determination of human aging is still far from being completely understood. Further mechanistic understanding of stem cell aging is required before it can be translated into human antiaging therapy. We all are trying to find the “magic bullet” that delays the natural aging process.

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